This study investigates health related quality of life of patients with irritable bowel syndrome (IBS).Seventy three patients with IBS (diagnosed based on Rome- II by gastroenterologists) who were matched with 73 healthy subjects responded to GHQ-28. Data was analyzed using t-tests for two independent groups and step-by-step regression analyses. Results indicated
that health related quality of life of patients with IBS was significantly lower than those in the control group, and their somatization, anxiety, social dysfunction and depression were significantly higher than the control group. Results related to hypotheses were consistent with previous research, which confirm the need for dual methods of medical and psychological treatment.