Adolescence is an important developmental period that is characterized by heightened problems of adjustment. The purpose of this study was to determine the role of parental psychological well-being and parent-child interactions in explaining social adjustment of female adolescent students. The research method was descriptive correlational and predictive equation. The statistical population of this study included all female students of secondary school in Rasht in the second semester of the academic year 2018 at approximately 1100 and among them, 273 female students and their parents were selected randomly by multistage cluster sampling method according to Morgan's table. Sin and Singh Student Adjustment questionnaire was completed by means of students and Reif psychological well-being and Fine et al parent-child relationship questionnaires were completed by means of parent. Data were analyzed using Pearson Correlation Coefficient and multiple regression analysis. The findings of this study showed that there is a significant relationship between parental psychological well-being and parent-child interactions with social adjustment in female students (P<0.05). Also, hate / loss of mother's role is negative and self-acceptance, mother's communication, domination of environment, independence, positive emotions of the mother, and mother's identity are positive and in total, 50% of the changes in the social adjustment of female students are explained (P <0.01). Based on this, it can be concluded that the psychological well-being of parents and the parent-child interactions play a role in social adjustment of female adolescent students.