Comprehensiveness of the Five Factor/Big Five model of personality has always been under question. Recent lexical and statistical research in various languages and cultures has shown that the personality structure could be well explained by a six factor model. These six factors comprised the HEXACO model, and are Honesty-Humility, Emotionality, eXtraversion, Agreeableness, Conscientiousness, and Openness to Experience. The purpose of this study was to investigate the relations among the HEXACO model of personality, subjective well-being (SWB), and religious orientation. Also, the current research has addressed the question of how much religion’s relations to SWB indices (including happiness and life satisfaction) are due to personality factors. 224 Iranian and 222 Polish volunteer college students, after providing the demographics, completed the HEXACO Personality Inventory (HEXACO-60), Religious Orientation Scale-Revised (ROS-R), Subjective Happiness Scale (SHS), and Satisfaction with Life Scale (SLS). Results showed that, within both the Iranian and the Polish context, religiosity was associated positively with the Honesty-Humility, Agreeableness, and Conscientiousness factors. Honesty-Humility was the strongest personality correlate of religiosity. Also, within both contexts, eXtraversion was the strongest predictor of happiness and life satisfaction. Results also showed that the religiosity-SWB relation was positive, weak, and to some degree due to personality factors. This study introduced the HEXACO model of personality structure, as well as underlined the efficiency of this new model in predicting individual differences in two important areas of human life, religiosity and wellbeing.