This research was conducted to examine the efficacy of emotion focused therapy on the severity of depression in patients with major depression. emotion focused therapy as a neo-humanistic approach, by integrating and up-to-dating person-centered, gestalt, and existential therapies, and focusing on emotional processing gathered a good deal of experimental supports abroad. In this single-case design, the efficacy of the mentioned therapy was examined on three participants (two women and one man) suffering from major depression. To evaluate the consistency of therapeutic effects, the findings were followed for two months. Depression and the severity of it, was assessed by using structured clinical interview for DSM-IV-TR (SCID) and Beck Depression Inventory-II (BDI-II), respectively. General remission percentage of this index was 77%. The findings suggest that emotion focused therapy has high efficacy on reducing the severity of depression. Two months follow up results indicated the consistency of patients’ remission during this period.